• Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Sanikini, Harinakshi; Muller, David C.; Sophiea, Marisa; Rinaldi, Sabina; Agudo, Antonio; Duell, Eric J.; Weiderpass, Elisabete; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Cervenka, Iris; Boeing, Heiner; Kaaks, Rudolf; Kühn, Tilman; Trichopoulou, Antonia; Martimianaki, Georgia; Karakatsani, Anna; Pala, Valeria; Palli, Domenico; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Skeie, Guri; Rylander, Charlotta; López, María-Dolores Chirlaque; Sánchez, Maria-Jose; Ardanaz, Eva; Regnér, Sara; Stocks, Tanja; Bueno-De-Mesquita, Bas; Vermeulen, Roel C.H.; Aune, Dagfinn; Tong, Tammy Y.N.; Kliemann, Nathalie; Murphy, Neil; Chadeau-Hyam, Marc; Gunter, Mark J.; Cross, Amanda J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-03)
      Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the ...
    • Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study 

      Baumeister, Sebastian E.; Schlesinger, Sabrina; Aleksandrova, Krasimira; Jochem, Carmen; Jenab, Mazda; Gunter, Marc J.; Overvad, Kim; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Fournier, Agnès; Kühn, Tilman; Kaaks, Rudolf; Pischon, Tobias; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; La Vecchia, Carlo; Masala, Giovanna; Panico, Salvatore; Fasanelli, Francesca; Tumino, Rosario; Grioni, Sara; Bueno-de-Mesquita, Hendrik Bastiaan; Vermeulen, Roel; May, Anne M.; Borch, Kristin Benjaminsen; Oyeyemi, Sunday Oluwafemi; Ardanaz, Eva; Rodríguez-Barranco, Miguel; Chirlaque López, María Dolores; Felez-Nobrega, Mireia; Sonestedt, Emily; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Mårten; Perez-Cornago, Aurora; Ferrari, Pietro; Stepien, Magdalena; Freisling, Heinz; Tsilidis, Konstantinos K.; Ward, Heather; Riboli, Elio; Weiderpass, Elisabete; Leitzmann, Michael F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-22)
      <i>Background & Aims</i> - To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).<p><p> <i>Methods</i> - We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder ...
    • Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control study 

      Fedirko, Veronika; Tran, Hao Quang; Gewirtz, Andrew T.; Stepien, Magdalena; Trichopoulou, Antonia; Aleksandrova, Krasimira; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Kühn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Bamia, Christina; Lagiou, Pagona; Grioni, Sara; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Naccarati, Alessio; Peeters, Petra H.; Bueno-De-Mesquita, Hendrik Bastiaan; Weiderpass, Elisabete; Castaño, José María Huerta; Barricarte, Aurelio; Sánchez, María-José; Dorronsoro, Miren; Quirós, José Ramón; Agudo, Antonio; Sjöberg, Klas; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Mårten; Bradbury, Kathryn E.; Khaw, Kay-Tee; Wareham, Nick; Tsilidis, Konstantinos K.; Aune, Dagfinn; Scalbert, Augustin; Romieu, Isabelle; Riboli, Elio; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-04)
      Background:<br>Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.<br>Methods:<br>We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide ...
    • Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies 

      Nimptsch, Katharina; Song, Mingyang; Aleksandrova, Krasimira; Katsoulis, Michail; Freisling, Heinz; Jenab, Mazda; Gunter, Marc J.; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Bueno-De-Mesquita, Hendrik Bastiaan; Chong, Dawn Q.; Jensen, Majken K.; Wu, Chunsen; Overvad, Kim; Kühn, Tilman; Barrdahl, Myrto; Melander, Olle; Jirström, Karin; Peeters, Petra H.; Sieri, Sabina; Panico, Salvatore; Cross, Amanda J.; Riboli, Elio; van Guelpen, Bethany; Myte, Robin; Huerta, José María; Rodriguez-Barranco, Miguel; Quirós, José Ramón; Dorronsoro, Miren; Tjønneland, Anne; Olsen, Anja; Travis, Ruth; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Severi, Gianluca; Bonet, Catalina; Palli, Domenico; Janke, Jürgen; Lee, Young-Ae; Boeing, Heiner; Giovannucci, Edward L.; Ogino, Shuji; Fuchs, Charles S.; Rimm, Eric; Wu, Kana; Chan, Andrew T.; Pischon, Tobias (Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-05-26)
      Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 ...
    • Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 European countries: A multinational cohort study 

      Murphy, Neil; Ward, Heather A.; Jenab, Mazda; Rothwell, Joseph A.; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Kvaskoff, Marina; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Aleksandrova, Krasimira; Weiderpass, Elisabete; Skeie, Guri; Borch, Kristin Benjaminsen; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Dahm, Christina C.; Jakszyn, Paula; Sánchez, María-José; Gil, Leire; Huerta, José María; Barricarte, Aurelio; Quirós, José Ramón; Khaw, Kay-Tee; Wareham, Nick; Bradbury, Kathryn E.; Trichopoulou, Antonia; La Vecchia, Carlo; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Fasanelli, Francesca; Panico, Salvatore; Bueno-de-Mesquita, Hendrik Bastiaan; Peeters, Petra H.M.; Gylling, Björn; Myte, Robin; Jirström, Karin; Berntsson, Jonna; Xue, Xiaonan; Riboli, Elio; Cross, Amanda J.; Gunter, Mark J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)
      <i>Background & Aims</i> - Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision.<p><p> <i>Methods</i> - In the European Prospective Investigation ...
    • Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition 

      Ward, Heather A.; Norat, Teresa; Overvad, Kim; Dahm, Christina C.; Bueno-de-Mesquita, H. Bas; Jenab, Mazda; Fedirko, Veronika; van Duijnhoven, Fränzel J.B.; Skeie, Guri; Romaguera-Bosch, Dora; Tjønneland, Anne; Olsen, Anja; Carbonnel, Franck; Affret, Aurélie; Boutron-Ruault, Marie-Christine; Katzke, Verena; Kühn, Tilman; Aleksandrova, Krassimira; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Bamia, Christina; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Naccarati, Alessio; Mattiello, Amalia; Peeters, Petra H.M.; Weiderpass, Elisabete; Åsli, Lene Angell; Jakszyn, Paula; Ramõn Quirõs, Jose; Sánchez, María-José; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Jirström, Karin; Ericson, Ulrika; Johansson, Ingegerd; Gylling, Björn; Bradbury, Kathryn E.; Khaw, Kay-Tee; Wareham, Nicholas J.; Stepien, Magdalena; Freisling, Heinz; Murphy, Neil; Cross, Amanda J.; Riboli, Elio (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-19)
    • Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in Western European populations 

      Fedirko, Veronika; Mandle, Hannah B.; Zhu, Wanzhe; Hughes, David J.; Siddiq, Afshan; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Bueno-de-Mesquita, Hendrik Bastiaan; van Duijnhoven, Fränzel J.B.; Siersema, Peter D.; Tjønneland, Anne; Olsen, Anja; Perduca, Vittorio; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Kühn, Tilman; Johnson, Theron; Krasimira, Aleksandrova; Trichopoulou, Antonia; Makrythanasis, Periklis; Thanos, Dimitris; Panico, Salvatore; Krogh, Vittorio; Sacerdote, Carlotta; Skeie, Guri; Weiderpass, Elisabete; Colorado-Yohar, Sandra; Sala, Núria; Barricarte, Aurelio; Sánchez, María-José; Quirós, Ramón; Amiano, Pilar; Gylling, Björn; Harlid, Sophia; Perez-Cornago, Aurora; Heath, Alicia K.; Tsilidis, Konstantinos K.; Aune, Dagfinn; Freisling, Heinz; Murphy, Neil; Gunter, Marc J.; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-20)
      Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, ...